Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death.

@article{Arboleda2010DifferentialRO,
  title={Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death.},
  author={Gonzalo Humberto Arboleda and Yolanda C{\'a}rdenas and Yeldy Rodr{\'i}guez and Luis Carlos Morales and Luisa Marina Matheus and Humberto Arboleda},
  journal={Neurotoxicology},
  year={2010},
  volume={31 6},
  pages={687-93}
}
Evidence has implicated apoptosis as a mechanism underlying cell demise in diverse neurodegenerative diseases including Parkinson's disease (PD). Endogenous toxins and other stress signals activate the sphingomyelin pathway increasing the levels of ceramide, an important regulator of cell death. In the present paper we have analysed the contribution of PI3K/AKT-GSK3β and MAPK (ERK and JNK) pathways to cell death in a catecholaminergic cell line following exposure to C(2)-ceramide. We also… CONTINUE READING

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