Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital

@article{Twyman1989DifferentialRO,
  title={Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital},
  author={R. Twyman and C. J. Rogers and R. Macdonald},
  journal={Annals of Neurology},
  year={1989},
  volume={25}
}
  • R. Twyman, C. J. Rogers, R. Macdonald
  • Published 1989
  • Chemistry
  • Annals of Neurology
  • The anticonvulsant activity of diazepam and phenobarbital may be mediated in part by enhancement of inhibition involving γ‐aminobutyric acid (GABA). While both diazepam and phenobarbital increase GABA receptor chloride current, they may have different mechanisms of action, since they bind to different sites on the GABA receptor—chloride channel complex. We used the patch clamp technique to compare the effects of diazepam and phenobarbital on single GABA receptor currents. Outside‐out patches… CONTINUE READING
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