Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital

  title={Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital},
  author={R. Twyman and C. J. Rogers and R. Macdonald},
  journal={Annals of Neurology},
  • R. Twyman, C. J. Rogers, R. Macdonald
  • Published 1989
  • Chemistry
  • Annals of Neurology
  • The anticonvulsant activity of diazepam and phenobarbital may be mediated in part by enhancement of inhibition involving γ‐aminobutyric acid (GABA). While both diazepam and phenobarbital increase GABA receptor chloride current, they may have different mechanisms of action, since they bind to different sites on the GABA receptor—chloride channel complex. We used the patch clamp technique to compare the effects of diazepam and phenobarbital on single GABA receptor currents. Outside‐out patches… CONTINUE READING
    279 Citations
    Context Dependent Benzodiazepine Modulation of GABAA Receptor Opening Frequency
    • M. Bianchi
    • Chemistry, Medicine
    • Current neuropharmacology
    • 2010
    • 18
    • PDF
    Direct Evidence For Diazepam Modulation of GABAA Receptor Microscopic Affinity
    • 113
    Hippocampal GABAAchannel conductance increased by diazepam
    • 158
    Terbium modulation of single gamma-aminobutyric acid-activated chloride channels in rat dorsal root ganglion neurons
    • 20
    • PDF
    The diversity of GABAA receptors
    • 290
    Mechanism of action of benzodiazepines on GABAA receptors
    • 138


    Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.
    • R. Study, J. L. Barker
    • Chemistry, Materials Science
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1981
    • 532
    • PDF
    Phenobarbitone modulation of postsynaptic GABA receptor function on cultured mammalian neurons
    • J. L. Barker, R. McBurney
    • Chemistry, Medicine
    • Proceedings of the Royal Society of London. Series B. Biological Sciences
    • 1979
    • 101
    GABA‐Benzodiazepine‐Barbiturate Receptor Interactions
    • R. Olsen
    • Chemistry, Medicine
    • Journal of neurochemistry
    • 1981
    • 883
    Anticonvulsant and anesthetic barbiturates
    • 96