Differential regulation of β2-adrenoceptor and adenosine A2B receptor signalling by GRK and arrestin proteins in arterial smooth muscle.

@article{Nash2018DifferentialRO,
  title={Differential regulation of β2-adrenoceptor and adenosine A2B receptor signalling by GRK and arrestin proteins in arterial smooth muscle.},
  author={Craig A. Nash and Carl Philip. Nelson and R. Mistry and Christian Moeller-Olsen and Elena D. Christofidou and R. A. John Challiss and J M Willets},
  journal={Cellular signalling},
  year={2018},
  volume={51},
  pages={
          86-98
        }
}
Generation of cAMP through Gs-coupled G protein-coupled receptor (GPCR) [e.g. β2-adrenoceptor (β2AR), adenosine A2B receptor (A2BR)] activation, induces arterial smooth muscle relaxation, counteracting the actions of vasoconstrictors. Gs-coupled GPCR signalling is regulated by G protein-coupled receptor kinases (GRK) and arrestin proteins, and dysregulation of Gs/GPCR signalling is thought play a role in the development of hypertension, which may be a consequence of enhanced GRK2 and/or… CONTINUE READING
BETA
4
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction.

  • American journal of physiology. Heart and circulatory physiology
  • 2008
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…