Differential regulation by the homologous response regulators NarL and NarP of Escherichia coli K-12 depends on DNA binding site arrangement.

@article{Darwin1997DifferentialRB,
  title={Differential regulation by the homologous response regulators NarL and NarP of Escherichia coli K-12 depends on DNA binding site arrangement.},
  author={Andrew J Darwin and K. L. Tyson and Stephen J W Busby and Valley J Stewart},
  journal={Molecular microbiology},
  year={1997},
  volume={25 3},
  pages={583-95}
}
The NarL and NarP proteins are homologous response regulators of Escherichia coli that control the expression of several operons in response to nitrate and nitrite. A consensus heptameric NarL DNA-binding sequence has been identified, and previous observations suggest that the NarP protein has a similar sequence specificity. However, some operons are regulated by NarL alone, whereas others are controlled by both NarL and NarP. In this study, DNase I footprinting experiments with the fdnG, nirB… CONTINUE READING