Differential regulation and action of estrogen receptors alpha and beta in GH3 cells.

@article{Mitchner1999DifferentialRA,
  title={Differential regulation and action of estrogen receptors alpha and beta in GH3 cells.},
  author={Natasha A Mitchner and Claire Garlick and Rosemary W Steinmetz and Nira Ben-Jonathan},
  journal={Endocrinology},
  year={1999},
  volume={140 6},
  pages={
          2651-8
        }
}
The pituitary lactotroph, a well established target for estrogens, expresses estrogen receptor-alpha (ER alpha) and -beta (ER beta). A truncated isoform of ER alpha, named TERP, is expressed in the pituitary, but not in the uterus. In this study we used the somatolactotroph cell line, GH3 cells, to examine 1) the expression of ER alpha, TERP, or ER beta and their regulation by estradiol; 2) the presence of receptor proteins; and 3) the effects of overexpressing ER beta or TERP on estrogen… CONTINUE READING