Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.

Abstract

The activation requirements of autoreactive CD4(+) T-cells were investigated in GAD65-specific HLA-DR0401-restricted clones derived from a diabetic patient using major histocompatibility complex (MHC) class II tetramers (TMrs) as stimulating agents. Despite the fact that TMrs loaded with an immunodominant-altered GAD peptide (TMr-GAD) bound a limited number… (More)

8 Figures and Tables

Topics

  • Presentations referencing similar topics