Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies.

@article{Sheahan1990DifferentialRO,
  title={Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies.},
  author={Kieran Sheahan and Michael J O'brien and B Burke and P A Dervan and J. C. O’keane and Leonard S. Gottlieb and Norman Zamcheck},
  journal={American journal of clinical pathology},
  year={1990},
  volume={94 2},
  pages={
          157-64
        }
}
To evaluate the role of carcinoembryonic antigen (CEA) in solving problems of tumor histogenesis in surgical pathology, monoclonal antibodies to four distinct epitopes of CEA (E-Z-EM) were applied to paraffin sections of 303 epithelial neoplasms from multiple sites. Two epitopes were CEA specific (D14 and B7.1), one was shared with nonspecific cross-reacting antigen (NCA) (B7.8), and the fourth (B18) was common to CEA, NCA, and biliary glycoprotein antigen (BGP). A sample of the tumors (n = 110… Expand
Carcinoembryonic Antigen Specificity and Affinity of Monoclonal Antibodies against Updated
The binding specificities of 52 well-characterized monoclonal antibod ies (Mabs) against Carcinoembryonic antigen (CEA) from 12 different research groups were studied by immunohistochemistry andExpand
Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen.
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The binding specificities of 52 well-characterized monoclonal antibodies against carcinoembryonic antigen (CEA) from 12 different research groups were studied by immunohistochemistry and immuno flow cytometry and there was a correlation between epitope group and binding specificity. Expand
Utility of CDX-2 in Distinguishing Between Primary and Secondary (Intestinal) Mucinous Ovarian Carcinoma: An Immunohistochemical Comparison of 43 Cases
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  • Biology, Medicine
  • The American journal of surgical pathology
  • 1998
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The equivalent binding of the five monoclonal anti‐CEA antibodies to most of the carcinomas tested suggests that this binding is due to the presence of complete CEA molecules and not only of crossreacting antigens. Expand
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