Differential proteome analysis of aging in rat skeletal muscle

@article{Piec2005DifferentialPA,
  title={Differential proteome analysis of aging in rat skeletal muscle},
  author={Isabelle Piec and A Listrat and Josette Alliot and Christophe Chambon and Richard G. Taylor and Daniel B{\'e}chet},
  journal={The FASEB Journal},
  year={2005},
  volume={19}
}
To identify the mechanisms underlying muscle aging, we have undertaken a high‐resolution differential proteomic analysis of gastrocnemius muscle in young adults, mature adults, and old LOU/c/jall rats. Two‐dimensional gel electrophoresis and subsequent MALDI‐ToF mass spectrometry analyses led to the identification of 40 differentially expressed proteins. Strikingly, most differences characterized old (30‐month) animals, whereas young (7‐month) and mature (18‐month) adults exhibited similar… Expand
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