Differential protein expressions induced by adenovirus-mediated p16 gene transfer into Balb/c nude mouse.

@article{Kim2003DifferentialPE,
  title={Differential protein expressions induced by adenovirus-mediated p16 gene transfer into Balb/c nude mouse.},
  author={O. Kim and Misun Park and Hoil Kang and Sinae Lim and Choon Taek Lee},
  journal={Proteomics},
  year={2003},
  volume={3 12},
  pages={2412-9}
}
To evaluate the safety of adenovirus-mediated gene transfer, we investigated differential protein expression after transducing adenoviral vector containing the p16(INK4a) tumor suppressor gene (Ad5CMV-p16) into Balb/c nude mice. We found that adenovirus-mediated p16(INK4a) gene transfer inhibited experimental lung metastasis, and that the intratumoral… CONTINUE READING