Differential protein expression following low temperature culture of suspension CHO-K1 cells

@article{Kumar2008DifferentialPE,
  title={Differential protein expression following low temperature culture of suspension CHO-K1 cells},
  author={Niraj Kumar and Patrick Gammell and Paula Meleady and Michael Henry and Martin M. Clynes},
  journal={BMC Biotechnology},
  year={2008},
  volume={8},
  pages={42 - 42}
}
BACKGROUND To ensure maximal productivity of recombinant proteins (rP) during production culture it is typical to encourage an initial phase of rapid cell proliferation to achieve high biomass followed by a stationary phase where cellular energies are directed towards production of rP. During many such biphasic cultures, the initial phase of rapid cell growth at 37 degrees C is followed by a growth arrest phase induced through reduction of the culture temperature. Low temperature induced growth… CONTINUE READING
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