Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency

Abstract

Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence of a complex tumor microenvironment. Those factors are a key obstacle for the treatment of this tumor type. To model the disease in mice, the current strategy is to grow GBM cells in serum-free non-adherent condition, which maintains their tumor-initiating… (More)
DOI: 10.1038/onc.2016.230

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