Differential processing of influenza nucleoprotein in human and mouse cells.

@article{Braud1998DifferentialPO,
  title={Differential processing of influenza nucleoprotein in human and mouse cells.},
  author={V{\'e}ronique M Braud and Andrew J McMichael and Vincenzo Cerundolo},
  journal={European journal of immunology},
  year={1998},
  volume={28 2},
  pages={625-35}
}
To investigate how early events in antigen processing affect the repertoire of peptides presented by MHC class I molecules, we compared the presentation of the influenza A nucleoprotein epitope 265-273 by HLA-A3 class I molecules in human and mouse cells. Mouse cells that express HLA-A3 failed to present the NP265-273 peptide when contained within the full-length nucleoprotein, to HLA-A3-restricted human cytotoxic T lymphocytes. However, when the epitope was generated directly in the cytosol… CONTINUE READING

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