Differential processing of influenza nucleoprotein in human and mouse cells.

  title={Differential processing of influenza nucleoprotein in human and mouse cells.},
  author={V{\'e}ronique M Braud and Andrew J McMichael and Vincenzo Cerundolo},
  journal={European journal of immunology},
  volume={28 2},
To investigate how early events in antigen processing affect the repertoire of peptides presented by MHC class I molecules, we compared the presentation of the influenza A nucleoprotein epitope 265-273 by HLA-A3 class I molecules in human and mouse cells. Mouse cells that express HLA-A3 failed to present the NP265-273 peptide when contained within the full-length nucleoprotein, to HLA-A3-restricted human cytotoxic T lymphocytes. However, when the epitope was generated directly in the cytosol… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Properties of MHC Class I Presented Peptides That Enhance Immunogenicity

PLoS Computational Biology • 2013
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…