Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases

  title={Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases},
  author={P. Kitabgi},
  • P. Kitabgi
  • Published 2006
  • Chemistry, Medicine
  • Peptides
  • Neurotensin (NT) is synthesized as part of a larger precursor that also contains neuromedin N (NN), a six amino acid neurotensin-like peptide. NT and NN are located in the C-terminal region of the precursor (pro-NT/NN) where they are flanked and separated by three Lys-Arg sequences. A fourth dibasic sequence is present in the middle of the precursor. Dibasics are the consensus sites recognized and cleaved by endoproteases that belong to the recently identified family of pro-protein convertases… CONTINUE READING
    23 Citations
    Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines.
    • P. Kitabgi
    • Chemistry, Medicine
    • Results and problems in cell differentiation
    • 2010
    • 18
    Neurotensin and its receptors in the control of glucose homeostasis
    • 23
    • Highly Influenced
    • PDF
    Balancing neurotrophin pathway and sortilin function: Its role in human disease.
    The Anti-Apoptotic Role of Neurotensin
    • 7
    • Highly Influenced
    • PDF


    Biosynthesis, Maturation, Release, and Degradation of Neurotensin and Neuromedin N
    • 67
    Differential processing of neurotensin/neuromedin N precursor(s) in canine brain and intestine.
    • 50
    Posttranslational Processing of the Neurotensin/Neuromedin‐N Precursor
    • 55