Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases

@article{Kitabgi2006DifferentialPO,
  title={Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases},
  author={P. Kitabgi},
  journal={Peptides},
  year={2006},
  volume={27},
  pages={2508-2514}
}
  • P. Kitabgi
  • Published 2006
  • Chemistry, Medicine
  • Peptides
  • Neurotensin (NT) is synthesized as part of a larger precursor that also contains neuromedin N (NN), a six amino acid neurotensin-like peptide. NT and NN are located in the C-terminal region of the precursor (pro-NT/NN) where they are flanked and separated by three Lys-Arg sequences. A fourth dibasic sequence is present in the middle of the precursor. Dibasics are the consensus sites recognized and cleaved by endoproteases that belong to the recently identified family of pro-protein convertases… CONTINUE READING
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