Differential polypeptide display: the search for the elusive target.

  title={Differential polypeptide display: the search for the elusive target.},
  author={Stefan Wittke and Thorsten Kaiser and Harald Mischak},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  volume={803 1},
Proteomics, as a tool to identify proteins in biological samples, is gaining rapidly importance in the postgenomic era. Here we discuss the current and potential role of different techniques in the field of proteomics such as two-dimensional gel electrophoresis off-line coupled to MALDI-MS (2D-PAGE-MALDI-MS), high performance liquid chromatography mass spectrometry (HPLC-MS), surface enhanced laser desorption/ionization mass spectrometry (SELDI-MS) and a newly developed technique, capillary… CONTINUE READING


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