Differential polymerase activity in avian and mammalian cells determines host range of influenza virus.

@article{Gabriel2007DifferentialPA,
  title={Differential polymerase activity in avian and mammalian cells determines host range of influenza virus.},
  author={G{\"u}lsah Gabriel and Maja Abram and Bjoern Keiner and Ralf Wagner and H D Klenk and J{\"u}rgen Stech},
  journal={Journal of virology},
  year={2007},
  volume={81 17},
  pages={9601-4}
}
As recently shown, mutations in the polymerase genes causing increased polymerase activity in mammalian cells are responsible for the adaptation of the highly pathogenic avian influenza virus SC35 (H7N7) to mice (G. Gabriel et al., Proc. Natl. Acad. Sci. USA 102:18590-18595, 2005). We have now compared mRNA, cRNA, and viral RNA levels of SC35 and its mouse-adapted variant SC35M in avian and mammalian cells. The increase in levels of transcription and replication of SC35M in mammalian cells was… CONTINUE READING

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