Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo.

@article{Grabarek2012DifferentialPO,
  title={Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo.},
  author={Joanna B Grabarek and Krystyna Zyzyńska and N{\'e}stor Saiz and Anna Piliszek and Stephen R Frankenberg and Jennifer Nichols and Anna-Katerina Hadjantonakis and Berenika Plusa},
  journal={Development},
  year={2012},
  volume={139 1},
  pages={
          129-39
        }
}
Cell differentiation during pre-implantation mammalian development involves the formation of two extra-embryonic lineages: trophoblast and primitive endoderm (PrE). A subset of cells within the inner cell mass (ICM) of the blastocyst does not respond to differentiation signals and forms the pluripotent epiblast, which gives rise to all of the tissues in the adult body. How this group of cells is set aside remains unknown. Recent studies documented distinct sequential phases of marker expression… CONTINUE READING

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