Differential placental gene expression in preeclampsia.

  title={Differential placental gene expression in preeclampsia.},
  author={Daniel A. Enquobahrie and Margaret Meller and Kenneth Rice and Bruce M. Psaty and David S Siscovick and Michelle A. Williams},
  journal={American journal of obstetrics and gynecology},
  volume={199 5},
OBJECTIVE Candidate genes that are associated with preeclampsia have not been described fully. We conducted microarray and confirmatory quantitative real time polymerase chain reaction studies to investigate global placental gene expression in preeclampsia. STUDY DESIGN RNA was extracted from placental samples that were collected from 18 preeclampsia cases and 18 normotensive control subjects. Oligonucleotide probes that represented 22,000 genes were used to measure gene expression in each… CONTINUE READING