Differential physiological roles of ESCRT complexes in Caenorhabditis elegans.

  title={Differential physiological roles of ESCRT complexes in Caenorhabditis elegans.},
  author={Dong-Wan Kim and Hyun Joo Sung and Donghyuk Shin and Haihong Shen and J. Ahnn and Sun-kyung Lee and Sangho Lee},
  journal={Molecules and cells},
  volume={31 6},
Endosomal sorting complex required for transport (ESCRT) complexes are involved in endosomal trafficking to the lysosome, cytokinesis, and viral budding. Extensive genetic, biochemical, and structural studies on the ESCRT system have been carried out in yeast and mammalian systems. However, the question of how the ESCRT system functions at the whole organism level has not been fully explored. In C. elegans, we performed RNAi experiments to knock-down gene expression of components of the ESCRT… CONTINUE READING


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