Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.

@article{Mller2008DifferentialPO,
  title={Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.},
  author={Cornelius M{\"u}ller and Kerstin Wassmann and Anja Berger and Stefan Holz and Sven Wassmann and Georg Nickenig},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={370 4},
  pages={669-74}
}
The AT1 receptor plays a pivotal role for the pathogenesis of hypertension and atherosclerosis. AT1 receptor expression is regulated posttranscriptionally via destabilization of the AT1 receptor mRNA by mRNA binding proteins. Recently, we identified calreticulin as a novel binding protein within the 3'untranslated region of the AT1 receptor mRNA. Calreticulin phosphorylation is essential for binding of the AT1 receptor mRNA. In crosslink experiments, we identified src kinase as the key enzyme… CONTINUE READING