Differential phospholipase C activation by phenylalkylamine serotonin 5‐HT2A receptor agonists

@article{Parrish2005DifferentialPC,
  title={Differential phospholipase C activation by phenylalkylamine serotonin 5‐HT2A receptor agonists},
  author={Jason Charles Parrish and Michael R. Braden and Emily Gundy and David E. Nichols},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={95}
}
Experiments compared a series of phenethylamine hallucinogens with their phenylisopropylamine analogues for binding affinity and ability to stimulate serotonin 5‐HT2A receptor‐mediated hydrolysis of phosphatidyl inositol in cells expressing cloned rat and human 5‐HT2A receptors. The (±)phenylisopropylamine analogues had significantly higher intrinsic activities for 5‐HT2A receptor‐mediated hydrolysis of phosphatidyl inositol compared to their phenethylamine analogues. With respect to the… 

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