Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice.

@article{Zhang1992DifferentialPO,
  title={Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice.},
  author={R. D. Zhang and Janet E. Price and Takahashi Fujimaki and Corazon D. Bucana and Isaiah Josh Fidler},
  journal={The American journal of pathology},
  year={1992},
  volume={141 5},
  pages={1115-24}
}
This study clarified whether and when the blood-brain barrier in experimental brain metastases is impaired by using hydrosoluble sodium fluorescein (MW 376) as a blood-brain barrier function indicator. Cells from eight human tumor lines (four melanomas, two breast carcinomas, one colon carcinoma, and one renal carcinoma) were inoculated into the internal carotid artery of nude mice. Brain metastases at different stages of development were sampled and the permeability of the blood-brain barrier… CONTINUE READING
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