Differential perikaryal localization in rats of D1 and D2 dopamine receptors on striatal projection neuron types identified by retrograde labeling.

@article{Deng2006DifferentialPL,
  title={Differential perikaryal localization in rats of D1 and D2 dopamine receptors on striatal projection neuron types identified by retrograde labeling.},
  author={Yun-Ping Deng and Wan-Long Lei and Anton Reiner},
  journal={Journal of chemical neuroanatomy},
  year={2006},
  volume={32 2-4},
  pages={101-16}
}
The localization of D1 and D2 dopamine receptors to striatal projection neuron types has been controversial, with some data favoring segregation of D1 to direct pathway neurons (substance P-containing) and D2 to indirect pathway neurons (enkephalinergic), and others reporting significant colocalization of D1 and D2 on individual projection neuron types. In the present study, we used subtype-specific antibodies against D1 and D2 and confocal laser scanning microscopy to determine their… CONTINUE READING

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