Differential peptide dynamics is linked to major histocompatibility complex polymorphism.

@article{Phlmann2004DifferentialPD,
  title={Differential peptide dynamics is linked to major histocompatibility complex polymorphism.},
  author={Thomas P{\"o}hlmann and Rainer A. B{\"o}ckmann and Helmut Grubm{\"u}ller and Barbara Uchańska-Ziegler and Andreas Ziegler and Ulrike Alexiev},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 27},
  pages={28197-201}
}
Peptide presentation by major histocompatibility complex (MHC) molecules is of central importance for immune responses, which are triggered through recognition of peptide-loaded MHC molecules (pMHC) by cellular ligands such as T-cell receptors (TCR). However, a unifying link between structural features of pMHC and cellular responses has not been established. Instead, pMHC/TCR binding studies suggest conformational and/or flexibility changes of the binding partners as a possible cause of… CONTINUE READING