Differential peptide binding motif for three juvenile arthritis associated HLA-DQ molecules.

@article{Ihle2003DifferentialPB,
  title={Differential peptide binding motif for three juvenile arthritis associated HLA-DQ molecules.},
  author={Johannes Ihle and Burkhard Fleckenstein and C. Terreaux and Hermann Beck and Ekkehard D. Albert and Guenther E. Dannecker},
  journal={Clinical and experimental rheumatology},
  year={2003},
  volume={21 2},
  pages={257-62}
}
OBJECTIVE In the oligoarticular subgroup of juvenile idiopathic arthritis, a strong association has been found with the expression of human leukocyte antigen class II molecules HLA-DQA1 *0401-DQB1*0402 and DQA1*0501-DQB1*0301, whereas DQA1*0501-DQB1*0201 is neutral and DQA1 *0201-DQB1*0201 protective. A presentation of different peptides by these DQ alleles would support their role in the disease process. METHODS Using a synthetic nonapeptide library, a peptide binding motif was determined… CONTINUE READING
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