Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers

@article{Kerkel2001DifferentialPO,
  title={Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers},
  author={Erja Kerkel{\"a} and Risto Ala-aho and Leila Jeskanen and Jouko Lohi and Reidar Axel Grenman and V M-K{\"a}h{\"a}ri and Ulpu K Saarialho-Kere},
  journal={British Journal of Cancer},
  year={2001},
  volume={84},
  pages={659 - 669}
}
Co-expression of several members of the matrix metalloproteinase (MMP) family is characteristic of human malignant tumours. To investigate the role of stromelysin-2 (MMP-10) in growth and invasion of skin tumours, we studied cutaneous carcinomas with high metastatic capacity (squamous cell carcinomas, SCCs), only locally destructive tumours (basal cell carcinomas, BCCs) and pre-malignant lesions (Bowen’s disease and actinic keratosis) using in situ hybridization. Expression of MMP-10 was… CONTINUE READING
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