Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers

  title={Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers},
  author={Erja Kerkel{\"a} and Risto Ala-aho and Leila Jeskanen and Jouko Lohi and Reidar Axel Grenman and V M-K{\"a}h{\"a}ri and Ulpu K Saarialho-Kere},
  journal={British Journal of Cancer},
  pages={659 - 669}
Co-expression of several members of the matrix metalloproteinase (MMP) family is characteristic of human malignant tumours. To investigate the role of stromelysin-2 (MMP-10) in growth and invasion of skin tumours, we studied cutaneous carcinomas with high metastatic capacity (squamous cell carcinomas, SCCs), only locally destructive tumours (basal cell carcinomas, BCCs) and pre-malignant lesions (Bowen’s disease and actinic keratosis) using in situ hybridization. Expression of MMP-10 was… CONTINUE READING
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Heino J and Kähäri VM (1997a) Collagenase-3 (MMP-13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis

  • N Johansson, J Westermarck, +4 authors J Peltonen
  • 1997
Highly Influential
4 Excerpts

Cloning of the genes for human stromelysin and stromelysin 2 : differential expression in rheumatoid synovial fibroblasts

  • B Skyldberg, S Salo, +4 authors G Auer
  • Biochemistry
  • 1999
1 Excerpt

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