Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil.

@article{Engber1998DifferentialPO,
  title={Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil.},
  author={Thomas M Engber and Elizabeth J Koury and Steven A. Dennis and Merl Miller and Patricia C. Contreras and Raghavendra V. Bhat},
  journal={Neuroscience letters},
  year={1998},
  volume={241 2-3},
  pages={95-8}
}
We examined the neuronal targets in the rat brain for the novel wakefulness-promoting agent modafinil and for amphetamine using c-Fos immunohistochemistry. Both modafinil and amphetamine induced neuronal expression of c-Fos-like immunoreactivity in the paraventricular nucleus of the hypothalamus, anterior hypothalamus and central nucleus of the amygdala. Modafinil also increased c-Fos-like immunoreactivity in the suprachiasmatic nucleus, while amphetamine had no effect. Brain regions in which… CONTINUE READING
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