Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil

  title={Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil},
  author={Thomas M. Engber and Elizabeth J. Koury and Shelley A Dennis and Matthew S. Miller and Patricia C. Contreras and Ratan V. Bhat},
  journal={Neuroscience Letters},

Environmental Novelty Differentially Affects c-fosmRNA Expression Induced by Amphetamine or Cocaine in Subregions of the Bed Nucleus of the Stria Terminalis and Amygdala

The data suggest that the context in which psychostimulants are given powerfully and differentially alters the response of limbic structures that have been functionally implicated in drug reinforcement and emotional behaviors.

Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness

Modafinil may promote waking via activation of TMN and orexin neurons, two regions implicated in the promotion of normal wakefulness, and Selective pharmacological activation of these hypothalamic regions may represent a novel approach to inducing wakefulness.

Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study.

Results suggest that modafinil blocks the reuptake of Noradrenaline by the noradrenergic terminals on sleep-promoting neurons from the VLPO, suggesting that such a mechanism could be at least partially responsible for the wake-promoted effect of modafInil.

Amphetamine-Induced Fos is Reduced in Limbic Cortical Regions but not in the Caudate or Accumbens in a Genetic Model of NMDA Receptor Hypofunction

A neuroanatomically selective activation deficit to amphetamine challenge in the NR1-deficient mice is suggested, which may have relevance to the hypothesized NMDA receptor hypofunction in schizophrenia.

Effects of differential rearing on amphetamine-induced c-fos expression in rats.

Functional internal complexity of amygdala: focus on gene activity mapping after behavioral training and drugs of abuse.

The studies on the gene activity markers, confronted with other approaches involving neuroanatomy, physiology, and the lesion method, have revealed novel aspects of the amygdala, especially pointing to functional heterogeneity of this brain region that does not fit very well into contemporarily active debate on serial versus parallel information processing within the amygdala.



Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat.

  • J. LinY. HouM. Jouvet
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
Evidence is provided for the potential brain targets of modafinil, which differ from those of amphetamine or methylphenidate, and suggest that modaf inil induces wakefulness by mechanisms distinct from Those of the two stimulants.

Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum.

It is proposed that differential activation of immediate-early genes by psychostimulants may be an early step in drug-specific molecular cascades contributing to acute and long-lasting psychostIMulant-induced changes in behavior.

Amygdaloid control of alerting and behavioral arousal in rats: involvement of serotonergic mechanisms.

An important role is demonstrated for the amygdala in the control of behavioral state and alerting mechanisms and it is suggested that 5-HT exerts some of its regulatory effects via an influence on forebrain regions.

Expression of c-fos protein in brain: metabolic mapping at the cellular level.

Fos immunohistochemistry provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways in response to polysynaptic activation.

Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat

It is hypothesized that the histaminergic descending afferents in the MPT would promote cortical desynchronization and W, at least partially, via activation of H1 receptors situated on cholinergic neurons and that the interactions between Histaminergic and cholin allergic neurons constitute an important circuit in cortical activation during W.

D1 Dopamine Receptor Activation of Multiple Transcription Factor Genes in Rat Striatum

It is demonstrated that striatal D1 dopamine receptors are coupled to activation of multiple transcription factor genes, including zif268 and jun‐B as well as members of the fos family.