Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions.

@article{Ruegg1987DifferentialPO,
  title={Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions.},
  author={Charles Edward. Ruegg and A. Carmelo Gandolfi and Raymond B. Nagle and Klaus Diether Brendel},
  journal={Toxicology and applied pharmacology},
  year={1987},
  volume={90 2},
  pages={
          261-73
        }
}
The innate susceptibility of renal cell types to these agents was investigated using precision-cut rabbit renal cortical slices made perpendicular to the cortical-papillary axis. Slices were incubated in DME/F12 medium containing 10 microM, 100 microM, or 1 mM concentrations of either metal for 12 hr or in Krebs-Hepes buffer gassed with nitrogen (100%) for 0.75 to 5 hr of hypoxic exposure. To simulate postischemic reperfusion, some slices were transferred to vessels gassed with oxygen after an… CONTINUE READING
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