Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle human red blood cells.

@article{Gibson1998DifferentialOS,
  title={Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle human red blood cells.},
  author={John S Gibson and Paul F Speake and J. Clive Ellory},
  journal={The Journal of physiology},
  year={1998},
  volume={511 ( Pt 1)},
  pages={
          225-34
        }
}
1. K+ influx and efflux were measured in normal (HbA) and sickle (HbS) red blood cells to investigate the interaction of swelling, H+ ions and urea with O2 (0 to 150 mmHg O2) in the presence of ouabain and bumetanide (both 100 microM). 2. In HbA cells, K+-C1- cotransport was O2 dependent. At low oxygen tensions (PO2s) the transporter was inactive and refractory to low pH, swelling or urea. 3. C1--independent K+ influxes in sickle cells were elevated at low PO2s, as previously reported. C1… CONTINUE READING
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