Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols.

@article{Ibarretxe2006DifferentialOS,
  title={Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols.},
  author={Gaskon Ibarretxe and M Victoria S{\'a}nchez-g{\'o}mez and Mar{\'i}a del Rosario Campos-Esparza and Elena Alberdi and Carlos Matute},
  journal={Glia},
  year={2006},
  volume={53 2},
  pages={201-11}
}
Oligodendrocytes are vulnerable to overactivation of both their AMPA receptors and their high- and low-affinity kainate receptors. Depending on the intensity of the insult and the type of receptor activated, excitotoxic oligodendrocyte death mediated by these receptors has different characteristics. One important consequence at a cellular level is the ensuing oxidative stress, related to Ca2+-dependent alterations in mitochondrial functioning. We observed that oxidative stress associated with… CONTINUE READING