Differential origin for endothelial and mesangial cells after transplantation of pig fetal renal primordia into rats.

@article{Takeda2006DifferentialOF,
  title={Differential origin for endothelial and mesangial cells after transplantation of pig fetal renal primordia into rats.},
  author={Shin-ichi Takeda and Sharon A. Rogers and Marc R. Hammerman},
  journal={Transplant immunology},
  year={2006},
  volume={15 3},
  pages={211-5}
}
Xenotransplantation of renal primordia in lieu of human kidney allografts has been proposed as a solution for the lack of organ availability. We and others have shown that growth and development of pig renal primordia occur post-transplantation across a highly disparate xenogenic barrier to rat. The origins (donor versus host) of endothelial cells (ECs) and mesangial cells (MCs) in grafts are incompletely delineated. In the present study, we investigated using immunohistochemistry, the origin… CONTINUE READING

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