Differential ontogenesis of D1 and D2 dopaminergic receptors in the chick embryo retina.

@article{Ventura1984DifferentialOO,
  title={Differential ontogenesis of D1 and D2 dopaminergic receptors in the chick embryo retina.},
  author={Ana L{\'u}cia Marques Ventura and William L. Klein and Fernando Garcia de Mello},
  journal={Brain research},
  year={1984},
  volume={314 2},
  pages={217-23}
}
The differentiation of D1 and D2 dopamine receptors was investigated during the ontogenesis of the chick embryo retina. Our results reveal an interesting complexity in dopaminergic differentiation, with one major receptor system developing before synapses and another one developing after. The dopamine-dependent increase of chick retina cAMP level differentiates early during retina ontogeny. By the embryonic day 10-11 10(-4) M dopamine and ADTN elicit a 13-fold increase in cAMP content of the… CONTINUE READING