Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals.

@article{Cai2009DifferentialNE,
  title={Differential nucleotide excision repair susceptibility of bulky DNA adducts in different sequence contexts: hierarchies of recognition signals.},
  author={Yuqin Cai and Dinshaw J. Patel and Nicholas E. Geacintov and Suse Broyde},
  journal={Journal of molecular biology},
  year={2009},
  volume={385 1},
  pages={30-44}
}
The structural origin underlying differential nucleotide excision repair (NER) susceptibilities of bulky DNA lesions remains a challenging problem. We investigated the 10S (+)-trans-anti-[BP]-N(2)-2'-deoxyguanosine (G*) adduct in double-stranded DNA. This adduct arises from the reaction, in vitro and in vivo, of a major genotoxic metabolite of benzo[a]pyrene (BP), (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, with the exocyclic amino group of guanine. Removal of… CONTINUE READING
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Structure and mechanism for DNA lesion recognition

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