Differential neurotensin responses to low and high doses of methamphetamine in the terminal regions of striatal efferents.

@article{Frankel2005DifferentialNR,
  title={Differential neurotensin responses to low and high doses of methamphetamine in the terminal regions of striatal efferents.},
  author={Paul S. Frankel and Amanda J. Hoonakker and Glen R. Hanson and Lloyd Bush and Kristen A. Keefe and Mario E. Alburges},
  journal={European journal of pharmacology},
  year={2005},
  volume={522 1-3},
  pages={47-54}
}
Neurotensin is a neuropeptide associated with basal ganglia dopaminergic neurons. Because levels of neurotensin in striatal tissue are differentially affected by low or high doses of methamphetamine, we employed microdialysis to assess the dose-dependent effects of methamphetamine on neurotensin release from the terminals of striatonigral and striatopallidal neurons. A low (0.5 mg/kg), but not high (10 mg/kg), dose of methamphetamine significantly increased nigral extracellular levels of… CONTINUE READING