Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine.

@article{Zhang2008DifferentialNI,
  title={Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine.},
  author={Wei-Wei Zhang and M Song and Yong-yao Cui and Hao Wang and Liang Zhu and Yin-yao Niu and Limin Yang and Yang Lu and HongZhuan Chen},
  journal={Neuroscience letters},
  year={2008},
  volume={443 3},
  pages={241-5}
}
Two naturally occurring tropane alkaloids, anisodamine and scopolamine, structurally dissimilar in one OH group, are well established as muscarinic acetylcholine receptor (mAChR) antagonists in clinic and basic research. However, experimental evidence for central effects of anisodamine is limited and conflicting compared with that of scopolamine. In the present study, Morris water maze test, long-term potentiation (LTP) recording and receptor radioligand binding assays were used to explore the… CONTINUE READING