Differential network entropy reveals cancer system hallmarks

  title={Differential network entropy reveals cancer system hallmarks},
  author={James A. West and Ginestra Bianconi and Simone Severini and Andrew E. Teschendorff},
  booktitle={Scientific reports},
The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is therefore of critical importance for gaining systems-level insights into disease mechanisms and ultimately for developing improved therapies. By integrating gene expression data with a protein interaction network we here demonstrate that cancer cells are characterised by an increase in network entropy. In addition, we… CONTINUE READING
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