Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes

@article{Alter2007DifferentialNK,
  title={Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes},
  author={Galit Alter and Maureen P. Martin and Nickolas Teigen and William H. Carr and Todd J. Suscovich and Arne Schneidewind and Hendrik Streeck and Michael T. Waring and Angela Meier and Christian Brander and Jeffrey D. Lifson and Todd M. Allen and Mary N. Carrington and Marcus Altfeld},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={3027 - 3036}
}
Decline of peak viremia during acute HIV-1 infection occurs before the development of vigorous adaptive immunity, and the level of decline correlates inversely with the rate of AIDS progression, implicating a potential role for the innate immune response in determining disease outcome. The combined expression of an activating natural killer (NK) cell receptor, the killer immunoglobulin-like receptor (KIR) 3DS1, and its presumed ligand, human leukocyte antigen (HLA)-B Bw4-80I, has been… 

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