Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease.

@article{Kruidenier2003DifferentialME,
  title={Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease.},
  author={Laurens Kruidenier and Ineke Kuiper and Wim van Duijn and Stefan Lars Marklund and Ruud A van Hogezand and Cornelis B. H. W. Lamers and Hein W. Verspaget},
  journal={The Journal of pathology},
  year={2003},
  volume={201 1},
  pages={7-16}
}
Mucosal tissue damage and dysfunction in chronic inflammatory bowel disease (IBD) are partly caused by an enduring exposure to excessive amounts of reactive oxygen metabolites (ROMs). Although the three human isoforms of superoxide dismutase (SOD), copper/zinc (Cu/Zn)-SOD, manganese (Mn)-SOD, and extracellular (EC)-SOD, form the primary endogenous defence against ROMs, their expression levels and cellular localization in IBD mucosa are largely unknown. The present study used enzyme-linked… CONTINUE READING