Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity.

Abstract

Knowledge of the effects of glucotoxic and lipotoxic environments on proglucagon producing intestinal L cells and pancreatic alpha cells is limited compared with pancreatic beta cells. This study compares the in vitro responses of these cell types to hyperglycaemia and hyperlipidaemia. Glucose (30 mM) and palmitate (0.5mM) reduced GLUTag and MIN6 cell… (More)
DOI: 10.1016/j.yexcr.2015.05.022

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@article{Vasu2015DifferentialMA, title={Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity.}, author={Srividya Vasu and Rachel Charlotte Moffett and Neville H. McClenaghan and Peter Raymond Flatt}, journal={Experimental cell research}, year={2015}, volume={336 1}, pages={100-8} }