Differential modulation of transcriptional activity of estrogen receptors by direct protein-protein interactions with the T cell factor family of transcription factors.

@article{ElTanani2001DifferentialMO,
  title={Differential modulation of transcriptional activity of estrogen receptors by direct protein-protein interactions with the T cell factor family of transcription factors.},
  author={Mohamed K. El-Tanani and David G Fernig and Roger Barraclough and Clare Green and P. Rudland},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={41675-82}
}
Two major signaling pathways, those triggered by estrogen (E(2)) and by the Wnt family, interact in the breast to cause growth and differentiation. The estrogen receptors ER(alpha) and ER(beta) are activated by binding E(2) and act as ligand-dependent transcription factors. The effector for the Wnt family is the Tcf family of transcription factors. Both… CONTINUE READING