Differential modulation of the renal and myocardial endothelin system by angiotensin II in Vivo. Effects of chronic selective ETA receptor blockade.

Abstract

Angiotensin II (Ang II) stimulates endothelin-1 (ET-1) production in glomerular endothelial and mesangial cells and in cardiac fibroblasts in vitro. We investigated the effects of Ang II in vivo (200 ng/kg/min for 2 weeks) with or without the ETA receptor antagonist LU135252 (50 mg/kg/day) on blood pressure, renal and myocardial ET-1 protein expression, and… (More)

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@article{Barton1998DifferentialMO, title={Differential modulation of the renal and myocardial endothelin system by angiotensin II in Vivo. Effects of chronic selective ETA receptor blockade.}, author={M. Barton and S. Shaw and Livius V D'uscio and P. Moreau and Thomas Felix L{\"u}scher}, journal={Journal of cardiovascular pharmacology}, year={1998}, volume={31 Suppl 1}, pages={S265-8} }