Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids.

@article{Morris1999DifferentialMO,
  title={Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids.},
  author={Kendall Morris and Charles N. Moorefield and Jahanshah Amin},
  journal={Molecular pharmacology},
  year={1999},
  volume={56 4},
  pages={752-9}
}
Gamma-aminobutyric acid type C receptor channels (GABA(C)Rs) composed of rho subunits are pharmacologically distinct from GABA(A) receptor channels (GABA(A)Rs). This difference is illustrated by the insensitivity of homo-oligomeric rho(1) receptor channels to many known modulators of GABA(A)Rs, such as barbiturates and benzodiazepines. A number of endogenous metabolites of corticosterone and progesterone, known as neuroactive steroids, compose yet another class of compounds that can modulate… CONTINUE READING

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