Differential modulation of the effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis.

@article{Weber1993DifferentialMO,
  title={Differential modulation of the effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis.},
  author={G{\"u}nther Weber and F. Link and Ernst Ferber and Paul G. Munder and D. Zeitter and Robert R. Bartlett and Kathryn Nixdorff},
  journal={Journal of immunology},
  year={1993},
  volume={151 1},
  pages={415-24}
}
We previously showed that a major protein isolated from purified cell walls of Proteus mirabilis (39-kDa protein) is a strong modulator of the specific immune responses to LPS from this bacterium in mice. When mixed with LPS before immunization, this protein enhances T cell-dependent, IgG antibody-producing cell responses specific for LPS. Furthermore, complexes of the 39-kDa protein with LPS drastically inhibit the production of oxygen radicals by murine macrophages activated with LPS, as… CONTINUE READING