Differential modulation of sodium channel Nav1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily

@article{Rush2006DifferentialMO,
  title={Differential modulation of sodium channel Nav1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily},
  author={Anthony M. Rush and Ellen K Wittmack and Lynda Tyrrell and Joel A. Black and Sulayman D. Dib-Hajj and Stephen G. Waxman},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={23}
}
FHF2A and FHF2B are two members of the fibroblast growth factor homologous factor 2 (FHF2) subfamily with distinct N termini. Using a generic antibody and electrophysiological methods, we previously showed that FHF2 is expressed in hippocampus and dorsal root ganglion (DRG) neurons and is colocalized with sodium channel Nav1.6 at sensory but not motor nodes of Ranvier, and that FHF2B associates with Nav1.6, causing an increase in current density and a small depolarizing shift in availability of… Expand
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  • W. Hsu, F. Scala, +12 authors F. Laezza
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2016
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