Differential modulation of reinforcement learning by D2 dopamine and NMDA glutamate receptor antagonism.

@article{Jocham2014DifferentialMO,
  title={Differential modulation of reinforcement learning by D2 dopamine and NMDA glutamate receptor antagonism.},
  author={Gerhard Jocham and Tilmann A. Klein and Markus Ullsperger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 39},
  pages={13151-62}
}
The firing pattern of midbrain dopamine (DA) neurons is well known to reflect reward prediction errors (PEs), the difference between obtained and expected rewards. The PE is thought to be a crucial signal for instrumental learning, and interference with DA transmission impairs learning. Phasic increases of DA neuron firing during positive PEs are driven by activation of NMDA receptors, whereas phasic suppression of firing during negative PEs is likely mediated by inputs from the lateral… CONTINUE READING
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