Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction.

@article{Junjhon2008DifferentialMO,
  title={Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction.},
  author={Jiraphan Junjhon and Matthawee Lausumpao and Sunpetchuda Supasa and Sansanee Noisakran and Adisak Songjaeng and Prakaimuk Saraithong and Kridsada Chaichoun and Utaiwan Utaipat and Poonsook Keelapang and Amornrat Kanjanahaluethai and Chunya Puttikhunt and Watchara Kasinrerk and Prida Malasit and Nopporn Sittisombut},
  journal={Journal of virology},
  year={2008},
  volume={82 21},
  pages={10776-91}
}
In the generation of flavivirus particles, an internal cleavage of the envelope glycoprotein prM by furin is required for the acquisition of infectivity. Unlike cleavage of the prM of other flaviviruses, cleavage of dengue virus prM is incomplete in many cell lines; the partial cleavage reflects the influence of residues at furin nonconsensus positions of the pr-M junction, as flaviviruses share basic residues at positions P1, P2, and P4, recognized by furin. In this study, viruses harboring… CONTINUE READING

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Structure of the immature dengue virus at low pH primes proteolytic maturation

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