Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes.

@article{Klein2002DifferentialMO,
  title={Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes.},
  author={Harald H. Klein and Stephanie Ullmann and Maren Drenckhan and Thomas Grimmsmann and Kirsten Unthan-Fechner and Irmelin Probst},
  journal={Journal of hepatology},
  year={2002},
  volume={37 4},
  pages={432-40}
}
BACKGROUND/AIMS Steroid diabetes is associated with hepatic insulin resistance; in hepatic cell models, however, mainly insulin-permissive effects have been described. Here we investigate modulation by dexamethasone of a larger number of insulin actions. METHODS Adult rat hepatocytes were cultured+/-dexamethasone for 48 h; insulin actions were studied subsequently. RESULTS Stimulation of glycolysis by insulin but not by glucose required culture with dexamethasone. Activation of glycogen… CONTINUE READING

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