Differential modulation of experimental autoimmune encephalomyelitis by α9*- and β2*-nicotinic acetylcholine receptors

@inproceedings{Simard2013DifferentialMO,
  title={Differential modulation of experimental autoimmune encephalomyelitis by α9*- and β2*-nicotinic acetylcholine receptors},
  author={Alain R Simard and Yan Gan and St{\'e}phanie St-Pierre and Ariana Kousari and Varun Patel and Paul Whiteaker and Barbara J Morley and Ronald J. Lukas and F D Shi},
  booktitle={Immunology and cell biology},
  year={2013}
}
Nicotine is a potent inhibitor of the immune response and is protective against experimental autoimmune encephalomyelitis (EAE). Initial studies suggested that the cholinergic system modulates inflammation via the α7-nicotinic acetylcholine receptor (nAChR) subtype. We recently have shown that effector T cells and myeloid cells constitutively express mRNAs encoding nAChR α9 and β2 subunits and found evidence for immune system roles for non-α7-nAChRs. In the present study, we assessed the… CONTINUE READING
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Characterization of Nicotinic Acetylcholine Receptor Knockout

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