Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.

@article{Tat2008DifferentialMO,
  title={Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.},
  author={Steeve Kwan Tat and Jean-Pierre Pelletier and Daniel Lajeunesse and Hassan Fahmi and Nicholas Duval and Johanne Martel-Pelletier},
  journal={Bone},
  year={2008},
  volume={43 2},
  pages={284-91}
}
BACKGROUND Osteoarthritis (OA) is the most common human joint disease. Recent studies suggest that an abnormal subchondral bone metabolism is intimately involved in the genesis of this disease. Bone remodelling is tightly regulated by a molecular triad composed of OPG/RANK/RANKL. RANKL exists as 3 isoforms: RANKL1, 2, and 3. RANKL1 and 2 enhance osteoclastogenesis whereas RANKL3 inhibits this phenomenon. We previously reported that human OA subchondral bone osteoblasts can be discriminated into… CONTINUE READING

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