Differential modulation of NMDA-induced calcium transients by arachidonic acid and nitric oxide in cultured hippocampal neurons.

@article{Richards2003DifferentialMO,
  title={Differential modulation of NMDA-induced calcium transients by arachidonic acid and nitric oxide in cultured hippocampal neurons.},
  author={D. A. Richards and Tim V.P. Bliss and Chistopher D Richards},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 11},
  pages={2323-8}
}
We have examined the effect of arachidonic acid on the transient increases in intracellular Ca2+ evoked by NMDA and AMPA in cultured hippocampal pyramidal cells loaded with Fura-2 AM. Repeated brief pulses of NMDA elicited Ca2+ transients that showed a modest run down. This run down was enhanced if the preparation was shielded from UV light and was reduced by conducting the experiments in the presence of the nitric oxide synthase inhibitor l-nitroarginine (100 micro m). Arachidonic acid (2… CONTINUE READING

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